Parallel Synthesis and Biological Evaluation of 837 Analogues of Procaspase-Activating Compound 1 (PAC-1)
نویسندگان
چکیده
منابع مشابه
Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1).
Procaspase-Activating Compound 1 (PAC-1) is an ortho-hydroxy N-acyl hydrazone that enhances the enzymatic activity of procaspase-3 in vitro and induces apoptosis in cancer cells. An analogue of PAC-1, called S-PAC-1, was evaluated in a veterinary clinical trial in pet dogs with lymphoma and found to have considerable potential as an anticancer agent. With the goal of identifying more potent com...
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ژورنال
عنوان ژورنال: ACS Combinatorial Science
سال: 2011
ISSN: 2156-8952,2156-8944
DOI: 10.1021/co2001372